Dr. Huganir is a Bloomberg Distinguished Professor in the Departments of Neuroscience and Psychological and Brain Sciences, Director of the Solomon H. Snyder Department of Neuroscience, and co-director of the Johns Hopkins Medicine Brain Science Institute at the Johns Hopkins University School of Medicine.
The Huganir laboratory has been investigating the molecular mechanisms in the regulation of neurotransmitter receptor function and synaptic transmission. Our studies of neurotransmitter receptors, including the major excitatory receptors in the brain, the glutamate receptors, demonstrate that protein phosphorylation of receptors is a major mechanism for the control of their function and is critical for the regulation of synaptic communication and learning and memory. Moreover, recent studies on the regulation of the synaptic localization of receptors have shown that receptor-associated proteins—such as the neuronal pentraxins, GRIP, PICK1, NSF, 4.1N and synGAP—are critical modulators of receptor synaptic targeting and synaptic plasticity. These studies demonstrate that the regulation of neurotransmitter receptor function plays a central role in the modulation of synaptic transmission and may be an important determinant in brain function and human behavior.
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West Bank, Sheffield, UK