The Rumbaugh laboratory is devoted to the understanding of how synapse and circuit mechanisms contribute to cognition and behavioral adaptions. In particular, we are interested in how major neurodevelopmental risk genes (i.e. genes that when mutated cause a defined neurodevelopmental disorder) disrupt synapse function and circuit connectivity. Our approach is to applying cutting edge technology to the study of synapse and circuit function both in vitro and in vivo to determine how major risk genes disrupt behavior and adaptive functions associated with neurodevelopmental disorders.
Neurodevelopmental disorder risk genes
Synapse function and neural circuit connectivity
Receptors and cell signaling
Learning, memory, and synaptic plasticity
Strong Collaborations + SYNGAP1 Research =
Accelerated Development of Better Treatments
West Bank, Sheffield, UK