Dr. Smith-Hicks completed her bachelors of science degree in biochemistry from the City College of New York (CUNY), Dr. Smith-Hicks entered the Medical Scientist Training Program at Columbia University College of Physicians and Surgeons, where she obtained her M.D., Ph.D. in 2000. She trained in Pediatrics at the Albert Einstein College of Medicine and completed her Neurology and Pediatric Neurology training at the Johns Hopkins University School of Medicine in 2005. Dr. Smith-Hicks trained as a post-doctoral fellow in the Department of Neuroscience at Johns Hopkins University School of Medicine under the guidance of Dr. Paul Worley. Dr. Smith-Hicks is interested in understanding how neurons are selected to integrate into networks. Her laboratory uses molecular, cell imagining, biochemical and electrophysiological techniques, as well as strategies that rely on the cellular reporting of active neurons from awake, behaving animals. She is exploring the effect of imbalance of excitation and inhibition on the ability of neurons to integrate into stable networks, with current projects directed at understanding the mechanisms of Fragile X Syndrome and Down syndrome. Her studies specifically examine the effect of novel and current experimental therapies on network formation and stability in mice.She is the Director of Basic Science Research for Fragile X. She joined the faculty at Kennedy Krieger Institute in 2010. Dr. Smith-Hicks is currently the Medical Director for the Center for Autism and Related Disorders, Co-Director, Rett Syndrome clinic and Director for SYNGAP1 Center of Excellence Clinic at Kennedy Krieger Institute. Her research interest includes behavioral phenotyping and biomarker identification.where she now sees patients with Autism Spectrum Disorder, SYNGAP1 and Rett Syndrome, while conducting basic science research exploring disorders of learning and memory.